Rest DAY
Cellular Autophagy by Art De Vany
Autophagy (self eating or consumption) is a crucial process in the cell. The cell consumes and recycles damaged internal material; this is an energy sparing process and important for scavenging old and damaged material within the cell. Autophagy is an important element in energy management and damage repair. The energy and protein content of damaged material is used to fuel rebuilding and cellular energetics.
The process seems to be triggered when the energy content of the cell declines so that the cell literally consumes itself. It goes after the damaged materials first, so there is a strong link between repair of damaged tissues and fasting or low energy state in the cell. So, it you are over-fed you down regulate cellular repair. You want to go hungy episodically to turn on cellular autophagy and repair those damaged tissues. On the other hand, when cell's energy level falls to just 30% of its storage capacity it executes its death program.
This makes a lot of sense from an evolutionary perspective. When the energy in the cell declines, the cell eats the damaged tissues for energy and that recycles the damaged tissues to make new material. The result is a healthier cell. It is efficient for the cell to turn to damaged materials first as a source of energy, thus sparing healthy tissues. So, in addition to fat, damaged internal materials of the cell are a source of energy. A fat person has a lot of damaged tissues inside cells and never recycles and repairs them because there is too much energy in the cell. When cellular energy falls too far, the cell forecasts its future energy intake (the notion of allostasis) and the future looks bleak, so it commits suicide.
Of course, exercise has the same effect because it lowers energy stores in the cells and also because it damages muscle cells, causing them to repair themselves through autophagy.
The process seems to be triggered when the energy content of the cell declines so that the cell literally consumes itself. It goes after the damaged materials first, so there is a strong link between repair of damaged tissues and fasting or low energy state in the cell. So, it you are over-fed you down regulate cellular repair. You want to go hungy episodically to turn on cellular autophagy and repair those damaged tissues. On the other hand, when cell's energy level falls to just 30% of its storage capacity it executes its death program.
This makes a lot of sense from an evolutionary perspective. When the energy in the cell declines, the cell eats the damaged tissues for energy and that recycles the damaged tissues to make new material. The result is a healthier cell. It is efficient for the cell to turn to damaged materials first as a source of energy, thus sparing healthy tissues. So, in addition to fat, damaged internal materials of the cell are a source of energy. A fat person has a lot of damaged tissues inside cells and never recycles and repairs them because there is too much energy in the cell. When cellular energy falls too far, the cell forecasts its future energy intake (the notion of allostasis) and the future looks bleak, so it commits suicide.
Of course, exercise has the same effect because it lowers energy stores in the cells and also because it damages muscle cells, causing them to repair themselves through autophagy.
Kero One....not well known...yet!
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